Tutorial: Library Research for the Life Sciences
Here's a sample citation and its accompanying abstract from BIOSIS:
Zidovetzki, R.; Sherman, I. W.; Prudhomme, J., et al.
Inhibition of Plasmodium falciparum lysophospholipase by anti-malarial drugs and sulphydryl reagents
Parasitology 108 (3) : 249-255 1994
Abstract:
The activity of lysophospholipase of human erythrocytes increased by about 3 orders of magnitude upon infection with Plasmodium falciparum. The apparent K-m for hydrolysis of lysophosphatidylcholine by this enzyme was 50 plus-minus 7 mu-M and the apparent V-max 6.8 plus-minus 0.6 nmol/h times 10-6 cells. The activity was Ca-2+ independent and had a broad pH maximum at pH 8. The enzyme was insensitive to such anti-malarials as mefloquine and arteether and was only weakly inhibited by chloroquine, with a 50% inhibition concentration (1C-50) of 70 mM. The anti-malarials quinine and quinacrine were more efficient inhibitors, with IC-50s of 2.6mM and 0.7 mM, respectively.
[This citation is to an article written by several UCR researchers.]
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